Expanding The Genetic Code iGEM Bielefeld-CeBiTec 2017

  title={Expanding The Genetic Code iGEM Bielefeld-CeBiTec 2017},
  author={Christina Drake and Saskia Dymek and Maximilian Edich and Markus Haak and Denise Kerkhoff and Melvin J. Liebers and Camilla M{\"a}rz and Laura Schl{\"u}ter and Olga Schmidt},
Fusing We designed and synthesized a novel ncAA called CBT-asparagine. It enables a highly specific covalent fusing reaction to another ncAA, cysteinyl-lysine. We confirmed the fusion in vitro via MS and successfully modeled several aaRS sequences for the translational incorporation of CBT-asparagine into proteins. Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein… CONTINUE READING


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