Corpus ID: 53693008

Expanding The Genetic Code iGEM Bielefeld-CeBiTec 2017

@inproceedings{Drake2018ExpandingTG,
  title={Expanding The Genetic Code iGEM Bielefeld-CeBiTec 2017},
  author={Christina Drake and Saskia Dymek and Maximilian Edich and M. Haak and D. Kerkhoff and Michelle Liebers and Camilla M{\"a}rz and Laura Schlüter and Olga Schmidt},
  year={2018}
}
  • Christina Drake, Saskia Dymek, +6 authors Olga Schmidt
  • Published 2018
  • Fusing We designed and synthesized a novel ncAA called CBT-asparagine. It enables a highly specific covalent fusing reaction to another ncAA, cysteinyl-lysine. We confirmed the fusion in vitro via MS and successfully modeled several aaRS sequences for the translational incorporation of CBT-asparagine into proteins. Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein… CONTINUE READING

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