Expanding Metabolic Networks: Scopes of Compounds, Robustness, and Evolution

  title={Expanding Metabolic Networks: Scopes of Compounds, Robustness, and Evolution},
  author={Thomas Handorf and Oliver Ebenh{\"o}h and Reinhart Heinrich},
  journal={Journal of Molecular Evolution},
A new method for the mathematical analysis of large metabolic networks is presented. Based on the fact that the occurrence of a metabolic reaction generally requires the existence of other reactions providing its substrates, series of metabolic networks are constructed. In each step of the corresponding expansion process those reactions are incorporated whose substrates are made available by the networks of the previous generations. The method is applied to the set of all metabolic reactions… CONTINUE READING
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