Expanded roles of two-component response regulator OmpR in Escherichia coli: genomic SELEX search for novel regulation targets.

@article{Shimada2015ExpandedRO,
  title={Expanded roles of two-component response regulator OmpR in Escherichia coli: genomic SELEX search for novel regulation targets.},
  author={Tomohiro Shimada and Hiraku Takada and Kaneyoshi Yamamoto and Akira Ishihama},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2015},
  volume={20 11},
  pages={915-31}
}
The two-component system (TCS) is a sophisticated bacterial signal transduction system for regulation of genome transcription in response to environmental conditions. The EnvZ-OmpR system is one of the well-characterized TCS of Escherichia coli, responding to changes in environmental osmolality. Regulation has largely focused on the differential expression of two porins, OmpF and OmpC, which transport small molecules across the outer membrane. Recently, it has become apparent that OmpR serves a… CONTINUE READING