Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila.

@article{Livens2005ExpandedPP,
  title={Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila.},
  author={Jean-Charles Li{\'e}vens and Thomas Rival and Magali Ich{\'e} and H{\'e}rve Chneiweiss and Serge Birman},
  journal={Human molecular genetics},
  year={2005},
  volume={14 5},
  pages={
          713-24
        }
}
Huntington's disease (HD) is a late onset heritable neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) sequence in the protein huntingtin (Htt). Transgenic models in mice have suggested that the motor and cognitive deficits associated to this disease are triggered by extended neuronal and possibly glial dysfunction, whereas neuronal death occurs late and selectively. Here, we provide in vivo evidence that expanded polyQ peptides antagonize epidermal growth factor receptor… CONTINUE READING

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