Expanded microbial genome coverage and improved protein family annotation in the COG database

@inproceedings{Galperin2015ExpandedMG,
  title={Expanded microbial genome coverage and improved protein family annotation in the COG database},
  author={Michael Y. Galperin and Kira S. Makarova and Yuri I. Wolf and Eugene V. Koonin},
  booktitle={Nucleic Acids Research},
  year={2015}
}
Microbial genome sequencing projects produce numerous sequences of deduced proteins, only a small fraction of which have been or will ever be studied experimentally. This leaves sequence analysis as the only feasible way to annotate these proteins and assign to them tentative functions. The Clusters of Orthologous Groups of proteins (COGs) database (http://www.ncbi.nlm.nih.gov/COG/), first created in 1997, has been a popular tool for functional annotation. Its success was largely based on (i… CONTINUE READING
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