Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment.

@article{Ceccatelli1991ExpandedDO,
  title={Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment.},
  author={Sandra Ceccatelli and Patrik Ernfors and Marcelo Jos{\'e} Villar and H{\aa}kan Persson and Tomas G M H{\"o}kfelt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 22},
  pages={10352-6}
}
The effect of intracerebroventricular injection of the mitosis inhibitor colchicine on expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 was studied in the rat brain with in situ hybridization. Colchicine up-regulates mRNA for NGF and BDNF in many of the neuronal systems normally expressing these factors. In addition, after colchicine treatment NGF and BDNF mRNAs were localized in several brain areas where they normally cannot be… CONTINUE READING
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