Expanded cohorts of maternal CD8+ T-cells specific for paternal MHC class I accumulate during pregnancy.

@article{Zhou1998ExpandedCO,
  title={Expanded cohorts of maternal CD8+ T-cells specific for paternal MHC class I accumulate during pregnancy.},
  author={Meixia Zhou and Andrew L Mellor},
  journal={Journal of reproductive immunology},
  year={1998},
  volume={40 1},
  pages={47-62}
}
A recombinant H-2Kb transgene, GK, containing the human HLA-G gene promoter is expressed throughout the trophoblast when inherited paternally. Male GK transgenic mice were mated with female T-cell receptor (TCR) transgenic mice to assess the effect of fetal H-2Kb expression on maternal H-2Kb-specific CD8+ T-cells during pregnancy. The number of maternal H-2Kb-specific CD8+ T-cells in spleen increased significantly (approximately 3-fold) 10 days post coitus when the GK transgene was inherited… CONTINUE READING