Expanded analysis of benzo[a]pyrene-DNA adducts formed in vitro and in mouse skin: their significance in tumor initiation.

@article{Chen1996ExpandedAO,
  title={Expanded analysis of benzo[a]pyrene-DNA adducts formed in vitro and in mouse skin: their significance in tumor initiation.},
  author={L. C. -M. Chen and Prabu D Devanesan and Sheila M. Higginbotham and Freek Ariese and Ryszard Jankowiak and Gerald J. Small and Eleanor G. Rogan and Ercole L Cavalieri},
  journal={Chemical research in toxicology},
  year={1996},
  volume={9 5},
  pages={897-903}
}
This paper reports expanded analyses of benzo[a]pyrene (BP)-DNA adducts formed in vitro by activation with horseradish peroxidase (HRP) or 3-methylcholanthrene-induced rat liver microsomes and in vivo in mouse skin. The adducts formed by BP are compared to those formed by BP-7,8-dihydrodiol and anti-BP diol epoxide (BPDE). First, activation of BP by HRP produced 61% depurinating adducts: 7-(benzo[a]pyrene-6-yl)guanine (BP-6-N7Gua), BP-6-C8Gua, BP-6-N7Ade, and the newly identified BP-6-N3Ade. As… CONTINUE READING
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