Expanded activity of dimer nucleases by combining ZFN and TALEN for genome editing

  title={Expanded activity of dimer nucleases by combining ZFN and TALEN for genome editing},
  author={Wei Yan and Cory Smith and Linzhao Cheng},
  booktitle={Scientific reports},
Our ability to precisely and efficiently edit mammalian and plant genomes has been significantly improved in recent years, partially due to increasing use of designer nucleases that recognize a pre-determined DNA sequence, make a specific DNA double-strand break, and stimulate gene targeting. A pair of zinc finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs) that recognize two adjacent unique DNA sequences dimerize through the fused FokI nuclease domain and cut… CONTINUE READING
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