Expanded T cell receptor Vβ-restricted T cells from patients with sporadic inclusion body myositis are proinflammatory and cytotoxic CD28null T cells.

@article{Pandya2010ExpandedTC,
  title={Expanded T cell receptor Vβ-restricted T cells from patients with sporadic inclusion body myositis are proinflammatory and cytotoxic CD28null T cells.},
  author={Jayesh M. Pandya and Andreas E. R. Fasth and Mei Zong and Snj{\'o}laug Arnardottir and Lara Dani and Eva Lindroos and Vivianne Malmstr{\"o}m and Ingrid E Lundberg},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 11},
  pages={3457-66}
}
OBJECTIVE Sporadic inclusion body myositis (IBM) is characterized by T cell infiltrates in muscle tissue, but their functional role is unclear. Systemic signs of inflammation are lacking, and the absence of beneficial effects following immunosuppression has challenged the notion of a role for the immune system. This study was undertaken to investigate the phenotype and functionality of T cells, specifically a subset of proinflammatory, cytotoxic, and apoptosis-resistant T cells defined as CD28… CONTINUE READING
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