Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.

@article{Li2010ExpandedCB,
  title={Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.},
  author={Jie Li and Igor I. Kuzin and Safiehkhatoon Moshkani and Steven T Proulx and Lianping Xing and Denise Skrombolas and Robert Dunn and I. Alvarez Javier Sanz and Edward M Schwarz and Andrea Bottaro},
  journal={Journal of immunology},
  year={2010},
  volume={184 11},
  pages={
          6142-50
        }
}
Anti-CD20 B cell depletion therapy (BCDT) is very effective for some patients with rheumatoid arthritis (RA); however the pathogenic role of B lymphocytes in RA and the primary targets of BCDT are unknown. The human TNF transgenic (hTNF-Tg) mouse model of RA displays a chronic, progressive disease that spreads from distal to proximal joints and is generally considered to be adaptive immune system independent. We have previously reported that knee arthritis in hTNF-Tg mice is accompanied by… CONTINUE READING
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