Expanded: a gene involved in the control of cell proliferation in imaginal discs.

  title={Expanded: a gene involved in the control of cell proliferation in imaginal discs.},
  author={M Boedigheimer and Allen Laughon},
  volume={118 4},
The expanded gene was first identified by a spontaneous mutation that causes broad wings. We have identified an enhancer-trap insertion within expanded and used it to generate additional mutations, including one null allele. expanded is an essential gene, necessary for proper growth control of imaginal discs and, when mutant, causes either hyperplasia or degeneration depending on the disc. Wing overgrowth in expanded hypermorphs is limited to specific regions along the anterior-posterior and… CONTINUE READING

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