Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.

@article{Nakamura2014ExpandableMC,
  title={Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.},
  author={Sou Nakamura and Naoya Takayama and Shinji Hirata and Hideya Seo and Hiroshi Endo and Kiyosumi Ochi and Ken-Ichi Fujita and Tomo Koike and Ken-ichi Harimoto and Takeaki Dohda and Akira Watanabe and Keisuke Okita and Nobuyasu Takahashi and Akira Sawaguchi and Shinya Yamanaka and Hiromitsu Nakauchi and Satoshi Nishimura and Koji Eto},
  journal={Cell stem cell},
  year={2014},
  volume={14 4},
  pages={535-48}
}
The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, we developed a clinically applicable strategy for the derivation of functional platelets from human pluripotent stem cells (PSCs). This approach involves the establishment of stable immortalized megakaryocyte progenitor cell lines (imMKCLs) from PSC-derived hematopoietic progenitors through the overexpression of BMI1 and BCL-XL to respectively suppress senescence and apoptosis… CONTINUE READING

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