Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

@article{Ramteke2015ExosomesSU,
  title={Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules},
  author={Anand M. Ramteke and Harold J. Ting and C. Agarwal and Samiha Mateen and Ranganatha R. Somasagara and A. Hussain and M. Graner and B. Frederick and R. Agarwal and G. Deep},
  journal={Molecular Carcinogenesis},
  year={2015},
  volume={54}
}
Hypoxic conditions in prostate cancer (PCA) are associated with poor prognosis; however, precise mechanism/s through which hypoxia promotes malignant phenotype remains unclear. Here, we analyzed the role of exosomes from hypoxic PCA cells in enhancing the invasiveness and stemness of naïve PCA cells, as well as in promoting cancer‐associated fibroblast (CAF) phenotype in prostate stromal cells (PrSC). Human PCA LNCaP and PC3 cells were exposed to hypoxic (1% O2) or normoxic (21% O2) conditions… Expand
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