Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

@article{Mineo2011ExosomesRB,
  title={Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion},
  author={Marco Mineo and S. H. Garfield and Simona Taverna and Anna Maria Flugy and Giacomo De Leo and Riccardo Alessandro and Elise C. Kohn},
  journal={Angiogenesis},
  year={2011},
  volume={15},
  pages={33-45}
}
Exosomes, microvesicles of endocytic origin released by normal and tumor cells, play an important role in cell-to-cell communication. Angiogenesis has been shown to regulate progression of chronic myeloid leukemia (CML). The mechanism through which this happens has not been elucidated. We isolated and characterized exosomes from K562 CML cells and evaluated their effects on human umbilical endothelial cells (HUVECs). Fluorescent-labeled exosomes were internalized by HUVECs during tubular… CONTINUE READING
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