Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus

  title={Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus},
  author={Robert Spaull and B. McPherson and Andriana Gialeli and A. Clayton and {\'O}. Cordero-Llana},
  journal={International Journal of Developmental Neuroscience},
  • Robert Spaull, B. McPherson, +2 authors Ó. Cordero-Llana
  • Published 2019
  • Medicine
  • International Journal of Developmental Neuroscience
  • Preterm infants are at risk of germinal matrix haemorrhage‐intraventricular haemorrhage (GMH‐IVH) which leads to post‐haemorrhagic hydrocephalus (PHH) in 30% of infants; this is associated with moderate‐severe neurodevelopmental impairment and confers significant risk of cerebral palsy. There are however no predictive indicators of the severity or long‐term outcome after GMH‐IVH. In recent years, endosome‐derived extracellular vesicles (EVs) or exosomes have been isolated from biofluids and… CONTINUE READING
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