Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver.

@article{Charrier2014ExosomesMI,
  title={Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver.},
  author={Alyssa L Charrier and Ruju Chen and Li Chen and Sherri Kemper and Takako Hattori and Masaharu Takigawa and David R Brigstock},
  journal={Surgery},
  year={2014},
  volume={156 3},
  pages={548-55}
}
BACKGROUND Fibrogenic pathways in the liver are principally regulated by hepatic stellate cells (HSC), which produce and respond to fibrotic mediators such as connective tissue growth factor (CCN2). The aim of this study was to determine whether CCN2 is shuttled between HSC in membranous nanovesicles, or "exosomes." METHODS Exosomes were incubated with HSC after isolation from conditioned medium of control or CCN2-green fluorescent protein (GFP)-transfected primary mouse HSC or human LX-2 HSC… CONTINUE READING

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