Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.

Abstract

UNLABELLED Resting CD4+ T lymphocytes resist human immunodeficiency virus (HIV) infection. Here, we provide evidence that exosomes from HIV-1-infected cells render resting human primary CD4+ T lymphocytes permissive to HIV-1 replication. These results were obtained with transwell cocultures of HIV-1-infected cells with quiescent CD4+ T lymphocytes in the… (More)
DOI: 10.1128/JVI.01712-14

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@article{Arenaccio2014ExosomesFH, title={Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.}, author={Claudia Arenaccio and Chiara Chiozzini and Sandra Columba-Cabezas and Francesco Manfredi and Elisabetta Affabris and Andreas S Baur and Maurizio Federico}, journal={Journal of virology}, year={2014}, volume={88 19}, pages={11529-39} }