Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.

@article{Zhou2018ExosomesFE,
  title={Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.},
  author={Yue Zhou and Pengfei Li and Andrew John Goodwin and James Allen Cook and Perry V. Halushka and Eugene Y. Chang and Hongkuan Fan},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2018},
  volume={26 5},
  pages={
          1375-1384
        }
}
Microvascular dysfunction leads to multi-organ failure and mortality in sepsis. Our previous studies demonstrated that administration of exogenous endothelial progenitor cells (EPCs) confers protection in sepsis as evidenced by reduced vascular leakage, improved organ function, and increased survival. We hypothesize that EPCs protect the microvasculature through the exosomes-mediated transfer of microRNAs (miRNAs). Mice were rendered septic by cecal ligation and puncture (CLP), and EPC exosomes… CONTINUE READING
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