Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression

  title={Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression},
  author={L. Wu and X. Zhang and B. Zhang and Hui Shi and X. Yuan and Yaoxiang Sun and Z. Pan and H. Qian and W. Xu},
  journal={Tumor Biology},
  • L. Wu, X. Zhang, +6 authors W. Xu
  • Published 2016
  • Chemistry, Medicine
  • Tumor Biology
  • Exosomes are nano-sized membrane vesicles secreted by both normal and cancer cells. Emerging evidence indicates that cancer cells derived exosomes contribute to cancer progression through the modulation of tumor microenvironment. However, the effects of exosomes derived from gastric cancer cells on macrophages are not well understood. In this study, we investigated the biological role of gastric cancer cells derived exosomes in the activation of macrophages. We demonstrated that gastric cancer… CONTINUE READING
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