Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression

@article{Wu2016ExosomesDF,
  title={Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression},
  author={Lijun Wu and Xu Zhang and Bin Zhang and Hui Shi and Xiao Yuan and Yaoxiang Sun and Zhaoji Pan and Hui Qian and Wenrong Xu},
  journal={Tumor Biology},
  year={2016},
  volume={37},
  pages={12169-12180}
}
Exosomes are nano-sized membrane vesicles secreted by both normal and cancer cells. Emerging evidence indicates that cancer cells derived exosomes contribute to cancer progression through the modulation of tumor microenvironment. However, the effects of exosomes derived from gastric cancer cells on macrophages are not well understood. In this study, we investigated the biological role of gastric cancer cells derived exosomes in the activation of macrophages. We demonstrated that gastric cancer… CONTINUE READING

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