Exosomes decrease sensitivity of breast cancer cells to adriamycin by delivering microRNAs

@article{Mao2015ExosomesDS,
  title={Exosomes decrease sensitivity of breast cancer cells to adriamycin by delivering microRNAs},
  author={Ling Mao and Jian Li and Wei-Xian Chen and Yan-qin Cai and Dan-dan Yu and Shan-liang Zhong and Jian-Hua Zhao and Jian-wei Zhou and Jin-Hai Tang},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={5247-5256}
}
While adriamycin (adr) offers improvement in survival for breast cancer (BCa) patients, unfortunately, drug resistance is almost inevitable. Mounting evidence suggests that exosomes act as a vehicle for genetic cargo and constantly shuttle biologically active molecules including microRNAs (miRNAs) between heterogeneous populations of tumor cells, engendering a resistance-promoting niche for cancer progression. Our recent study showed that exosomes from docetaxel-resistance BCa cells could… CONTINUE READING
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