Exosomes are natural carriers of exogenous siRNA to human cells in vitro

  title={Exosomes are natural carriers of exogenous siRNA to human cells in vitro},
  author={Tatyana A. Shtam and Roman A Kovalev and Elena Yu Varfolomeeva and Evgeny M. Makarov and Yury V. Kil and Michael V Filatov},
  booktitle={Cell Communication and Signaling},
Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA. As exosomes naturally carry RNA between cells, these particles might be useful in gene cancer therapy to deliver therapeutic short interfering RNA (siRNA) to the target cells. Despite the promise of RNA interference (RNAi) for use in therapy, several technical obstacles must be overcome. Exogenous siRNA is prone to degradation, has a limited… CONTINUE READING
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