Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

  title={Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells},
  author={H. Valadi and K. Ekstr{\"o}m and A. Bossios and Margareta Sj{\"o}strand and J. Lee and J. L{\"o}tvall},
  journal={Nature Cell Biology},
  • H. Valadi, K. Ekström, +3 authors J. Lötvall
  • Published 2007
  • Biology, Medicine
  • Nature Cell Biology
  • Exosomes are vesicles of endocytic origin released by many cells. These vesicles can mediate communication between cells, facilitating processes such as antigen presentation. Here, we show that exosomes from a mouse and a human mast cell line (MC/9 and HMC-1, respectively), as well as primary bone marrow-derived mouse mast cells, contain RNA. Microarray assessments revealed the presence of mRNA from approximately 1300 genes, many of which are not present in the cytoplasm of the donor cell. In… CONTINUE READING
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