Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins.

@article{Lancaster2005ExosomedependentTO,
  title={Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins.},
  author={Graeme Iain Lancaster and Mark Anthony Febbraio},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 24},
  pages={23349-55}
}
The heat shock proteins (HSPs) are a family of intracellular proteins found in all eukaryotes and prokaryotes. Their functions are well characterized and are central to maintaining cellular homeostasis and in promoting cell survival in response to stressful cellular conditions. However, several studies provide evidence that specific members of the HSP family might be secreted via an unidentified exocytotic pathway. Here we show that exosomes, small membrane vesicles that are secreted by… CONTINUE READING
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