Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment.

@article{Whiteside2018ExosomeAM,
  title={Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment.},
  author={Theresa L Whiteside},
  journal={Seminars in immunology},
  year={2018},
  volume={35},
  pages={69-79}
}
Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called "TEX" carry and deliver a cargo rich in proteins and… CONTINUE READING