Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1.

@article{Umezu2014ExosomalMS,
  title={Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1.},
  author={Tomohiro Umezu and Hiroko Tadokoro and Kenko Azuma and Seiichiro Yoshizawa and Kazuma Ohyashiki and Junko H Ohyashiki},
  journal={Blood},
  year={2014},
  volume={124 25},
  pages={3748-57}
}
Exosomes are small endosome-derived vesicles containing a wide range of functional proteins, mRNA, and miRNA. Exosomal miRNA from cancer cells helps modulate the microenvironment. In multiple myeloma (MM), the massive proliferation of malignant plasma cells causes hypoxia. To date, the majority of in vitro hypoxia studies of cancer cells have used acute hypoxic exposure (3-24 hours). Thus, we attempted to clarify the role of MM-derived exosomes in hypoxic bone marrow by using MM cells grown… CONTINUE READING
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Hypoxia - inducible factor ( HIF ) - 1 a suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

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