Exosomal MicroRNA Transfer Into Macrophages Mediates Cellular Postconditioning.

@article{Couto2017ExosomalMT,
  title={Exosomal MicroRNA Transfer Into Macrophages Mediates Cellular Postconditioning.},
  author={Geoffrey de Couto and Romain Gallet and Linda Cambier and Ervin Jaghatspanyan and Nupur Makkar and James Frederick Dawkins and Benjamin P. Berman and Eduardo Marb{\'a}n},
  journal={Circulation},
  year={2017},
  volume={136 2},
  pages={
          200-214
        }
}
BACKGROUND Cardiosphere-derived cells (CDCs) confer cardioprotection in acute myocardial infarction by distinctive macrophage (Mϕ) polarization. Here we demonstrate that CDC-secreted exosomes (CDCexo) recapitulate the cardioprotective effects of CDC therapy known as cellular postconditioning. METHODS Rats and pigs underwent myocardial infarction induced by ischemia/reperfusion before intracoronary infusion of CDCexo, inert fibroblast exosomes (Fbexo; control), or vehicle. Two days later… CONTINUE READING
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