Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3

@article{Diao2015ExosomalHM,
  title={Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3},
  author={Jianjun Diao and Xue Yang and Xuedong Song and Shiyou Chen and Yunfeng He and Qingsong Wang and Gang Chen and Chunli Luo and Xiao-hou Wu and Yao Zhang},
  journal={Medical Oncology},
  year={2015},
  volume={32},
  pages={1-10}
}
  • Jianjun Diao, Xue Yang, +7 authors Yao Zhang
  • Published in Medical Oncology 2015
  • Medicine, Biology
  • Myeloid-derived suppressor cells (MDSCs), one of the main cell populations, are responsible for regulating the immune response, which accumulates in tumor-bearing mice and humans contributing to cancer development. Exosomes produced by tumor cells have been involved in tumor-associated immune suppression. However, the role of exosomes is unclear in the activation of MDSCs. Here, we have purified tumor-derived exosomes from the supernatants of Renca cell cultures. Transmission electron… CONTINUE READING

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