Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+RORγt+/IL-10+FoxP3+ ratio in CD4+ T cells.

@article{Gudmundsdottir2015ExopolysaccharidesFC,
  title={Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+ROR$\gamma$t+/IL-10+FoxP3+ ratio in CD4+ T cells.},
  author={Asa B Gudmundsdottir and Sesselja {\'O}marsd{\'o}ttir and {\'A}sa Brynj{\'o}lfsd{\'o}ttir and Berit Smestad Paulsen and Elin S Olafsdottir and Jona Freysdottir},
  journal={Immunology letters},
  year={2015},
  volume={163 2},
  pages={
          157-62
        }
}
View on PubMed
bluelagoon.com
27 Citations
Highly Influential Citations
3
Background Citations
10
Methods Citations
1
Results Citations
2

Figures from this paper

27 Citations

Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes
Anti-Inflammatory Activity of Exopolysaccharides from Phormidium sp. ETS05, the Most Abundant Cyanobacterium of the Therapeutic Euganean Thermal Muds, Using the Zebrafish Model
TLDR
This work evaluated the therapeutic potential of exopolysaccharides (EPS) produced by Phormidium sp.
Phylogenetic, morphological and biochemical studies on Thermospirulina andreolii gen. & sp. nov. (Cyanophyta) from the Euganean Thermal District (Italy)
TLDR
Molecular, morphological and biochemical data supported the description of the microorganism as a new species, Thermospirulina andreolii, of the new genus ThermospIRulina, which includes other Spirulina-like cyanobacteria living in different thermal springs around the world.
Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris
TLDR
In vitro and in vivo animal experiments show that the EPS/CPT emulsion can effectively treat psoriasis vulgaris by increasing the accumulation of CPT in psoriatic skin lesions and reducing the levels of inflammatory cells and inflammatory factors.
Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ΔsigF mutant.
Influence of light and temperature on growth and high-value molecules productivity from Cyanobacterium aponinum
TLDR
Interestingly, this strain also had the ability to accumulate other high-value compounds such as phycocyanin, zeaxanthin, and β-carotene suggesting that C. aponinum can be used for the industrial production of multiple molecules of biotechnological interest.
Regulatory Dendritic Cells, T Cell Tolerance, and Dendritic Cell Therapy for Immunologic Disease
TLDR
The clinical relevance of human DCreg is addressed, highlighting the outcomes of pre-clinical mouse and non-human primate studies and early phase clinical trials that have been undertaken, as well as the impact of innate immune receptors and symbiotic microbial signaling on the immunobiology of DCreg.
Blue Lagoon Algae Improve Uneven Skin Pigmentation: Results from in vitro Studies and from a Monocentric, Randomized, Double-Blind, Vehicle-Controlled, Split-Face Study
TLDR
BL algae can affect human melanocyte function in vitro and reduce uneven facial skin pigmentation in vivo, as well as benefit patients with psoriasis.
Advances in Understanding the Immunological Pathways in Psoriasis
TLDR
There is now enough evidence to support the role of interleukin (IL), IL-17, IL-22, T helper (Th) -17 cells, Th-22 cells, T regulatory cells, transforming growth factor (TGF)-β1 and IL-10 in the pathogenesis of psoriasis vulgaris.
Strategies to Obtain Designer Polymers Based on Cyanobacterial Extracellular Polymeric Substances (EPS)
TLDR
An overview of the characteristics and biological activities of cyanobacterial EPS is provided, the challenges and opportunities to improve the amount and/or characteristics of the polymers are discussed, and the most relevant advances on the use of cyanOBacterial EPS as scaffolds, coatings, and vehicles for drug delivery are reported.
...
...

References

SHOWING 1-10 OF 23 REFERENCES
In vitro and in vivo immunomodulating effects of traditionally-prepared extract and purified compounds from Cetraria islandica
TLDR
Results suggest that the aqueous extract of C. islandica has an anti-inflammatory effect, possibly by changing the cytokine secretion bias from IL-12 towards IL-10, and not isolichenan or the secondary metabolites.
Lipopolysaccharide-Activated IL-10-Secreting Dendritic Cells Suppress Experimental Autoimmune Uveoretinitis by MHCII-Dependent Activation of CD62L-Expressing Regulatory T Cells1
TLDR
It is proposed that IL-10-DC require MHCII-dependent Ag presentation, and hence TCR ligation, to promote CD62L-mediated trafficking of Tregs to the site of T effector cell priming, where they suppress autoimmunity.
Human CD1c (BDCA‐1)+ myeloid dendritic cells secrete IL‐10 and display an immuno‐regulatory phenotype and function in response to Escherichia coli
TLDR
Compared to their mouse CD8+ DC counterparts, human CD141+ DCs did not phagocytose or process E. coli‐derived Ag and failed to secrete cytokines in response to E.E. coli.
Th17 cells in human disease
TLDR
Given the strong association between excessive Th17 activity and human disease, new therapeutic approaches targeting Th17 cells are highly promising, but the potential safety of such treatments may be limited by the role of these cells in normal host defenses against infection.
Interleukin-17 in inflammatory skin disorders
TLDR
Whereas IL-17 may play an important role in the pathogenesis of psoriasis and contact hypersensitivity, its role in atopic dermatitis is still unclear.
Polysaccharide biological response modifiers.
Mechanisms of Disease: Psoriasis.
TLDR
Anti-TNF strategies have three variants: a humanized chimeric anti–TNF- α monoclonal antibody, a fully human monocolonal anti-T NF- α antibody, and a human p75 TNF-receptor Fc fusion protein.
Dysfunctional Blood and Target Tissue CD4+CD25high Regulatory T Cells in Psoriasis: Mechanism Underlying Unrestrained Pathogenic Effector T Cell Proliferation1
TLDR
Dysfunctional blood and target tissue CD4+CD25high Treg cell activity may lead to reduced restraint and consequent hyperproliferation of psoriatic pathogenic T cells in vivo, which represents a critical component of human organ-specific autoimmune disease.
Cyanobacterial bioactive molecules--an overview of their toxic properties.
TLDR
This review collates the information available on the diverse types of toxic bioactive molecules produced by cyanobacteria and provides pointers for effective exploitation of these biologically and industrially significant prokaryotes.
CD4 T cells: fates, functions, and faults.
TLDR
Much of what is known about the 4 CD4 T-cell subsets is summarized, including the history of their discovery, their unique cytokine products and related functions, their distinctive expression of cell surface receptors and their characteristic transcription factors, the regulation of their fate determination, and the consequences of their abnormal activation.
...
...