Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis

@inproceedings{Mizuno2011Exophilin8TC,
  title={Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis},
  author={Kouichi Mizuno and Jos{\'e} S Ramalho and Tetsuro Izumi},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Exophilin8/MyRIP/Slac2-c is an effector protein of the small GTPase Rab27a and is specifically localized on retinal melanosomes and secretory granules. We investigated the role of exophilin8 in insulin granule trafficking. Exogenous expression of exophilin8 in pancreatic β cells or their cell line, MIN6, polarized (exophilin8-positive) insulin granules at the cell corners, where both cortical actin and the microtubule plus-end-binding protein, EB1, were present. Mutation analyses indicated that… CONTINUE READING
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