Exonucleolytic processing of small nucleolar RNAs from pre-mRNA introns.

@article{Kiss1995ExonucleolyticPO,
  title={Exonucleolytic processing of small nucleolar RNAs from pre-mRNA introns.},
  author={Tam{\'a}s G{\'a}bor Kiss and Witold Filipowicz},
  journal={Genes & development},
  year={1995},
  volume={9 11},
  pages={
          1411-24
        }
}
Many small nucleolar RNAs (snoRNAs) in vertebrates are encoded within introns of protein genes. We have reported previously that two isoforms of human U17 snoRNA are encoded in introns of the cell-cycle regulatory gene, RCC1. We have now investigated the mechanism of processing of U17 RNAs and of another intron-encoded snoRNA, U19. Experiments in which the processing of intronic RNA substrates was tested in HeLa cell extracts suggest that exonucleases rather than endonucleases are involved in… CONTINUE READING

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