Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.

  title={Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.},
  author={Jing Zhuang and Guochun Jiang and Henning Willers and Fen Xia},
  journal={The Journal of biological chemistry},
  volume={284 44},
DNA double-stranded breaks (DSBs) are lethal if not repaired and are highly mutagenic if misrepaired. Nonhomologous end joining (NHEJ) is one of the major DSB repair pathways and can rejoin the DSB ends either precisely or with mistakes. Recent evidence suggests the existence of two NHEJ subpathways: conservative NHEJ (C-NHEJ), which does not require microhomology and can join ends precisely; and deletional NHEJ (D-NHEJ), which utilizes microhomology to join the ends with small deletions… CONTINUE READING


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BIOLOGICAL CHEMISTRY 30573 at U iv of T oonto O C U L on M arch 5, 2015 hp://w w w .jb.org/ D ow nladed from and Fen

M. H. Yun, K. Hiom
Role of Mre11 in DNA End Joining OCTOBER • 2009

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