Exonization of active mouse L1s: a driver of transcriptome evolution?

@article{Zemojtel2007ExonizationOA,
  title={Exonization of active mouse L1s: a driver of transcriptome evolution?},
  author={Tomasz Zemojtel and Tobias Penzkofer and Joerg Schultz and Thomas Dandekar and Richard Badge and Martin Vingron},
  journal={BMC Genomics},
  year={2007},
  volume={8},
  pages={392 - 392}
}
Long interspersed nuclear elements (LINE-1s, L1s) have been recently implicated in the regulation of mammalian transcriptomes. Here, we show that members of the three active mouse L1 subfamilies (A, GF and TF) contain, in addition to those on their sense strands, conserved functional splice sites on their antisense strands, which trigger multiple exonization events. The latter is particularly intriguing in the light of the strong antisense orientation bias of intronic L1s, implying that the… CONTINUE READING
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