Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.

@article{Gebhardt2010ExonskippingSV,
  title={Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.},
  author={Florian M. Gebhardt and Ann D. Mitrovic and Daniel Friedrich Gilbert and Robert J Vandenberg and Joseph W Lynch and Peter Ronald Dodd},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 41},
  pages={
          31313-24
        }
}
The glial transporter excitatory amino acid transporter-2 (EAAT2) is the main mediator of glutamate clearance in brain. The wild-type transporter (EAAT2wt) forms trimeric membrane complexes in which each protomer functions autonomously. Several EAAT2 variants are found in control and Alzheimer-diseased human brains; their expression increases with pathological severity. These variants might alter EAAT2wt-mediated transport by abrogating membrane trafficking, or by changing the configuration or… CONTINUE READING
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