Exon shuffling by L1 retrotransposition.

  title={Exon shuffling by L1 retrotransposition.},
  author={John V Moran and Ralph J DeBerardinis and Haig H. Kazazian},
  volume={283 5407},
Long interspersed nuclear elements (LINE-1s or L1s) are the most abundant retrotransposons in the human genome, and they serve as major sources of reverse transcriptase activity. Engineered L1s retrotranspose at high frequency in cultured human cells. Here it is shown that L1s insert into transcribed genes and retrotranspose sequences derived from their 3' flanks to new genomic locations. Thus, retrotransposition-competent L1s provide a vehicle to mobilize non-L1 sequences, such as exons or… CONTINUE READING
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