Exon expression profiling reveals stimulus-mediated exon use in neural cells

@article{McKee2007ExonEP,
  title={Exon expression profiling reveals stimulus-mediated exon use in neural cells},
  author={Adrienne E McKee and Nicola Neretti and Lu{\'e}s Eduardo Ramos de Carvalho and Clifford A. Meyer and Edward Alan Fox and Alexander Brodsky and Pamela A. Silver},
  journal={Genome Biology},
  year={2007},
  volume={8},
  pages={R159 - R159}
}
Neuronal cells respond to changes in intracellular calcium ([Ca2+]i) by affecting both the abundance and architecture of specific mRNAs. Although calcium-induced transcription and transcript variation have both been recognized as important sources of gene regulation, the interplay between these two phenomena has not been evaluated on a genome-wide scale. Here, we show that exon-centric microarrays can be used to resolve the [Ca2+]i-modulated gene expression response into transcript-level and… CONTINUE READING

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