Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing

@inproceedings{Viso2012ExonCA,
  title={Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing},
  author={Florencia del Viso and Dipankan Bhattacharya and Yong Kong and Michael J Gilchrist and Mustafa K. Khokha},
  booktitle={BMC Genomics},
  year={2012}
}
Exome sequencing has transformed human genetic analysis and may do the same for other vertebrate model systems. However, a major challenge is sifting through the large number of sequence variants to identify the causative mutation for a given phenotype. In models like Xenopus tropicalis, an incomplete and occasionally incorrect genome assembly compounds this problem. To facilitate cloning of X. tropicalis mutants identified in forward genetic screens, we sought to combine bulk segregant… CONTINUE READING
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