Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.

@article{Lin2009ExonAP,
  title={Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.},
  author={Eva Lin and Li Li and Yinghui Guan and R Ollero Soriano and Celina Sanchez Rivers and Sankar Mohan and A Pandita and Jerry Tang and Zora Modrusan},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 9},
  pages={1466-76}
}
The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as an oncogene in a subset of non-small cell lung cancers (NSCLC). We used profiling of cancer genomes on an exon array to develop a novel computational method for the global search of gene rearrangements. This approach led to the detection of EML4-ALK fusion in breast and colorectal carcinomas in addition to NSCLC. Screening of a large collection of patient tumor samples… CONTINUE READING
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