Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome.

@article{Orio2003Exon6A,
  title={Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome.},
  author={Francesco Orio and Giuseppe Matarese and Sebastiano Di Biase and Stefano Palomba and Donato Labella and Veronica Sanna and Silvia Savastano and Fulvio Zullo and Annamaria Colao and Gaetano Lombardi},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 12},
  pages={
          5887-92
        }
}
  • Francesco Orio, Giuseppe Matarese, +7 authors Gaetano Lombardi
  • Published in
    The Journal of clinical…
    2003
  • Medicine
  • Obesity affects about 44% of women with polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is one of the genes involved in the differentiation of adipose tissue. In an attempt to shed light on the high percentage of obesity in PCOS, we examined polymorphisms at exons 6 and 2 of the PPAR-gamma gene in 100 PCOS patients and in 100 healthy controls matched for age and body mass index (BMI). The T allele frequency of exon 6 was significantly higher (P… CONTINUE READING

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