Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens.

@article{Birkenstock2012ExometabolomeAI,
  title={Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens.},
  author={Timo A Birkenstock and Manuel Liebeke and Volker Winstel and Bernhard Krismer and Cordula Gekeler and Maria J Niemiec and Hans Bisswanger and Michael Lalk and Andreas Peschel},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 4},
  pages={2887-95}
}
The desperate need for new therapeutics against notoriously antibiotic-resistant bacteria has led to a quest for novel antibacterial target structures and compounds. Moreover, defining targets and modes of action of new antimicrobial compounds remains a major challenge with standard technologies. Here we characterize the antibacterial properties of triphenylbismuthdichloride (TPBC), which has recently been successfully used against device-associated infections. We demonstrate that TPBC has… CONTINUE READING