Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

@inproceedings{Tang2015ExomewideAA,
  title={Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese},
  author={Clara Sze-Man Tang and He Zhang and Chloe Y. Y. Cheung and Ming Jiang Xu and Jenny C. Y. Ho and Wei Zhou and Stacey Shawn Cherny and Yan Zhang and Oddgeir Lingaas Holmen and K K Au and Haiyi Yu and Lin Hao Xu and Jia Jia and Robert Milan Porsch and Lijie Sun and Weixian Xu and Huiping Zheng and L. C. Wong and Yiming Mu and Jingtao Dou and Carol H. Y. Fong and Shuyu Wang and Xueyu Hong and Liguang Dong and Yanhua Liao and Jiansong Wang and Levina Suk Mi Lam and Xi Su and Hua Yan and Min-lee Yang and Jin Chen and Chung Wah Siu and Gaoqiang Xie and Yu-Cho Woo and Yangfeng Wu and Kathryn C. B. Tan and Kristian Hveem and B. M. Y. Cheung and Sebastian Z{\"o}llner and Aimin Xu and Y. Eugene Chen and Chaoqiang Jiang and Y Jonathan Zhang and Tai Hing Lam and Santhi K. Ganesh and Yong Huo and Pak C. Sham and Karen S. L. Lam and Cristen J. Willer and Hung-Fat Tse and Wei Gao},
  booktitle={Nature communications},
  year={2015}
}
Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P<2.69 × 10(-7)), including three Asian-specific coding variants in known genes (CETP p.Asp459Gly… CONTINUE READING