Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.

@article{Cutcutache2015ExomewideSS,
  title={Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.},
  author={Ioana Cutcutache and Yuka Suzuki and Iain Beehuat Tan and Subhashini Ramgopal and Shenli Zhang and Kalpana Ramnarayanan and Anna Gan and Heng Hong Lee and Su Ting Tay and Aikseng Ooi and Choon Kiat Ong and Jonathan Todd Bolthouse and Brian R Lane and John G. Anema and Richard J. Kahnoski and Patrick O. B. Tan and Bin Tean Teh and Steven G Rozen},
  journal={European urology},
  year={2015},
  volume={68 1},
  pages={77-83}
}
BACKGROUND Testicular germ cell tumors are the most common cancer diagnosed in young men, and seminomas are the most common type of these cancers. There have been no exome-wide examinations of genes mutated in seminomas or of overall rates of nonsilent somatic mutations in these tumors. OBJECTIVE The objective was to analyze somatic mutations in seminomas to determine which genes are affected and to determine rates of nonsilent mutations. DESIGN, SETTING, AND PARTICIPANTS Eight seminomas… CONTINUE READING