Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.

  title={Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.},
  author={N. D. de Miranda and Konstantinos Georgiou and L. Chen and Chenglin Wu and Zhibo Gao and A. Zaravinos and Susana Lisboa and G. Enblad and M. Teixeira and Yi-Xin Zeng and Roujun Peng and Q. Pan-Hammarstr{\"o}m},
  volume={124 16},
  • N. D. de Miranda, Konstantinos Georgiou, +9 authors Q. Pan-Hammarström
  • Published 2014
  • Biology, Medicine
  • Blood
  • Next-generation sequencing studies on diffuse large B-cell lymphomas (DLBCLs) have revealed novel targets of genetic aberrations but also high intercohort heterogeneity. Previous studies have suggested that the prevalence of disease subgroups and cytogenetic profiles differ between Western and Asian patients. To characterize the coding genome of Chinese DLBCL, we performed whole-exome sequencing of DNA derived from 31 tumors and respective peripheral blood samples. The mutation prevalence of… CONTINUE READING
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