Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

@article{Keersmaecker2013ExomeSI,
  title={Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia},
  author={Kim de Keersmaecker and Zeynep Kalender Atak and Ning Li and Carmen Vicente and Stephanie Patchett and Tiziana Girardi and Valentina Gianfelici and Ellen Geerdens and Emmanuelle Clappier and Micha{\"e}l Porcu and Idoya Lahortiga and Rossella Luc{\`a} and Jiekun Yan and Gert Hulselmans and Hilde Vranckx and Roel Vandepoel and Bram Sweron and Kris Jacobs and Nicole Mentens and Iwona Wlodarska and Barbara Cauwelier and Jacqueline Cloos and J Steve Soulier and Anne Uyttebroeck and Claudia Bagni and Bassem A Hassan and Peter Vandenberghe and Arlen W Johnson and Stein Aerts and Jan Cools},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={186-190}
}
T-cell acute lymphoblastic leukemia (T-ALL) is caused by the cooperation of multiple oncogenic lesions. We used exome sequencing on 67 T-ALLs to gain insight into the mutational spectrum in these leukemias. We detected protein-altering mutations in 508 genes, with an average of 8.2 mutations in pediatric and 21.0 mutations in adult T-ALL. Using stringent filtering, we predict seven new oncogenic driver genes in T-ALL. We identify CNOT3 as a tumor suppressor mutated in 7 of 89 (7.9%) adult T… CONTINUE READING
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