Exome sequencing identifies an MLL3 gene germ line mutation in a pedigree of colorectal cancer and acute myeloid leukemia.

@article{Li2013ExomeSI,
  title={Exome sequencing identifies an MLL3 gene germ line mutation in a pedigree of colorectal cancer and acute myeloid leukemia.},
  author={Weidong Li and Qing-rong Li and Shuang-nian Xu and Feng-Jiang Wei and Z Ye and Jinke Cheng and Jieping Chen},
  journal={Blood},
  year={2013},
  volume={121 8},
  pages={1478-9}
}
Recently, the frequently mutated gene MLL3 was found to be related to the pathogenesis of hepatocellular carcinoma (HCC), fluke-associated cholangiocarcinoma, gastric cancer, and transitional carcinoma of the bladder,1-4 raising the possibility that the MLL3 gene and its encoded chromatin remodeling protein MLL3 are etiologically related to cancers. We performed exome sequencing for 4 patients in a multigenerational pedigree with colorectal cancers and acute myeloid leukemia (AML) and… CONTINUE READING