Exome sequencing generates high quality data in non-target regions

@inproceedings{Guo2012ExomeSG,
  title={Exome sequencing generates high quality data in non-target regions},
  author={Yan Guo and Jirong Long and Jing He and Chung-I Li and Qiuyin Cai and Xiao-Ou Shu and Wei Zheng and Chun Xing Li},
  booktitle={BMC Genomics},
  year={2012}
}
BackgroundExome sequencing using next-generation sequencing technologies is a cost efficient approach to selectively sequencing coding regions of human genome for detection of disease variants. A significant amount of DNA fragments from the capture process fall outside target regions, and sequence data for positions outside target regions have been mostly ignored after alignment.ResultWe performed whole exome sequencing on 22 subjects using Agilent SureSelect capture reagent and 6 subjects… CONTINUE READING

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