Exome Sequencing and Linkage Analysis Identified Tenascin-C (TNC) as a Novel Causative Gene in Nonsyndromic Hearing Loss

@inproceedings{Zhao2013ExomeSA,
  title={Exome Sequencing and Linkage Analysis Identified Tenascin-C (TNC) as a Novel Causative Gene in Nonsyndromic Hearing Loss},
  author={Yali Zhao and Feifan Zhao and Liang Zong and Peng Zhou Zhang and Liping Guan and Jianguo Zhang and Dayong Wang and Jing Wang and Wei Chai and Lan Lan and Qian Shu Li and Bing Han and Ling Yang and Xin Jin and Weiyan Yang and Xiaoxiang Hu and Xiaoning Wang and Ning Li and Yingrui Li and Christine Petit and Jun Wang and Huanming Yang Jian Wang and Qiuju Wang},
  booktitle={PloS one},
  year={2013}
}
In this study, a five-generation Chinese family (family F013) with progressive autosomal dominant hearing loss was mapped to a critical region spanning 28.54 Mb on chromosome 9q31.3-q34.3 by linkage analysis, which was a novel DFNA locus, assigned as DFNA56. In this interval, there were 398 annotated genes. Then, whole exome sequencing was applied in three… CONTINUE READING