Exome Sequencing Reveals the Likely Involvement of SOX10 in Uveal Melanoma

  title={Exome Sequencing Reveals the Likely Involvement of SOX10 in Uveal Melanoma},
  author={Debodipta Das and I. Kaur and M. Ali and Nidhan K. Biswas and S. Das and S. Kumar and S. Honavar and A. Maitra and S. Chakrabarti and P. Majumder},
  journal={Optometry and Vision Science},
  • Debodipta Das, I. Kaur, +7 authors P. Majumder
  • Published 2014
  • Medicine
  • Optometry and Vision Science
  • Purpose To identify the spectrum of somatic mutations in an Asian Indian patient with uveal melanoma (UM) without metastasis using exome sequencing. Case Report A 49-year-old man from India was diagnosed as having cilio-choroidal (uveal) melanoma (UM), without metastasis, in his right eye with the help of magnetic resonance imaging. This was later confirmed by histopathological evaluation. Two individuals from India with non-neoplastic blind eyes were recruited as controls. The affected eyes… CONTINUE READING


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