Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction.

@article{He2010ExogenouslyAS,
  title={Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction.},
  author={Wei He and Lunan Zhang and Aiguo Ni and Zhiping Zhang and Maria Mirotsou and Lan Mao and Richard E. Pratt and Victor J. Dzau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 49},
  pages={21110-5}
}
Secreted frizzled related protein 2 (Sfrp2) is known as an inhibitor for the Wnt signaling. In recent studies, Sfrp2 has been reported to inhibit the activity of Xenopus homolog of mammalian Tolloid-like 1 metalloproteinase. Bone morphogenic protein 1 (Bmp1)/Tolloid-like metalloproteinase plays a key role in the regulation of collagen biosynthesis and maturation after tissue injury. Here, we showed both endogenous Sfrp2 and Bmp1 protein expressions were up-regulated in rat heart after… CONTINUE READING

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