Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.

@article{Drake1995ExogenousVE,
  title={Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.},
  author={Christopher J. Drake and Charles A. E. Little},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 17},
  pages={7657-61}
}
Vascular endothelial growth factor (VEGF) is a potent and specific endothelial mitogen that is able to induce angiogenesis in vivo [Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V. & Ferrara, N. (1989) Science 246 1306-1309]. To determine if VEGF also influences the behavior of primordial endothelial cells, we used an in vivo vascular assay based on the de novo formation of vessels. Japanese quail embryos injected with nanomolar quantities of the 165-residue form of VEGF at the onset… CONTINUE READING

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